Exploring and Validating the Molecular Mechanisms Linking Fatty Acid Metabolism and Sarcopenia.

ABSTRACT: Sarcopenia is an ageing-related disease characterised primarily by skeletal muscle functional decline. Despite of fatty acid metabolism (FAM) affecting oxidative stress within muscle tissue, the key roles of critical genes linking FAM and sarcopenia are unclear. The GSE8479, GSE1428, and GSE136344 datasets were downloaded and intersected for identifying FAM-related differentially expressed genes (FAMRDEGs) screened by enrichment analysis, LASSO regression, and Support Vector Machine (SVM) analyses. Cytoscape software was used for visualising mRNA-transcription factor (TF) and mRNA-miRNA networks. In addition, ROC curves of key genes were plotted to evaluate their diagnostic significance. A Fatty Acid Metabolism Score (FAM-Score) was conducted and immune cell infiltration analysis was condu

SUBMITTER: Yang R 

PROVIDER: S-EPMC12747248 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature