Urinary Metabolites and Survival in Malignant Mesothelioma.

ABSTRACT:

Background

Malignant mesothelioma is a rare and aggressive malignancy with limited treatment options and poor survival outcomes. Current biomarkers such as MESOMARK, fibulin-3, and osteopontin show diagnostic potential but remain hampered by inconsistent sensitivity and reproducibility. Urine-based metabolites may provide a simple, noninvasive alternative for prognosis and disease monitoring.

Methods

We evaluated whether four urinary metabolites-creatine riboside, N-acetylneuraminic acid, cortisol sulfate, and cholestane pentol-previously associated with prognosis in lung and liver cancer, are prognostic in mesothelioma. Urinary metabolite concentrations were quantified in a clinically annotated cohort with survival follow-up. Associations with overall survival and a validat

SUBMITTER: Toulabi L 

PROVIDER: S-EPMC12747252 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature