Hematological Consequences of Environmental Change During Dewilding of Rhesus Macaques.

ABSTRACT: The environment shapes immune system development and the regulation of inflammatory responses, which may affect the prevalence of immune mediated inflammatory diseases. However, the hematological consequences of a major environmental change, such as those experienced during migration, remain poorly understood. Here, we used cellular and molecular approaches to assess the immunological consequences in rhesus macaques as they transitioned from an outdoor provisioned environment to an indoor laboratory facility in a process we term 'dewilding.' Dewilding led to a sharp decrease in neutrophils and increased lymphocytes in the peripheral blood, a skewing toward a proinflammatory T_H1 response, and increased T cell activation. Concurrently, we observed changes in the microbiome, with f

SUBMITTER: Smith A 

PROVIDER: S-EPMC12747276 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature