Thyroid dysfunction in heart failure with preserved ejection fraction: A systematic review and meta-analysis.

ABSTRACT:

Background

Despite controversial findings regarding the association between thyroid hormones and heart failure with preserved ejection fraction (HFpEF), thyroid dysfunction is widely assumed to be independently associated with this condition. Herein, we sought to systematically review the existing literature and estimate the prevalence of thyroid dysfunction in patients with HFpEF.

Methods

We conducted a comprehensive search in PubMed, Scopus, Web of Science, Embase, and ProQuest up to the end of November 2024. Observational studies assessing thyroid dysfunction prevalence in patients with HFpEF were included in this study. The prevalence of overt thyroid dysfunction, low T3 syndrome, and subclinical hypothyroidism (SCH) was pooled using a random-effects model. Duval and Twe

SUBMITTER: Heidarpour M 

PROVIDER: S-EPMC12747304 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature