Global, regional, and national burden of kidney dysfunction-attributed ischemic heart disease from 1990 to 2021: A systematic analysis of the Global Burden of Disease study 2021.

ABSTRACT:

Background

Ischemic heart disease (IHD) remains a leading cause of global morbidity and mortality, with kidney dysfunction (KD) emerging as a critical independent risk factor. This study aimed to provide a comprehensive analysis of the global burden and trends of KD-attributed IHD from 1990 to 2021.

Methods

We analyzed data from the Global Burden of Disease (GBD) study 2021, covering 204 countries and territories from 1990 to 2021. We examined trends in mortality and disability-adjusted life years (DALYs) of KD-attributable IHD, with stratification by sex, age, and socio-demographic index (SDI). The association between burden and SDI was evaluated using Spearman's correlation coefficient, and a smoothed curve model was developed to analyze the stage of the association.

Re

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12747353 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature