Investigating the oxygen dependence of FLASH-RT using electron paramagnetic resonance imaging.

ABSTRACT:

Purpose

The FLASH effect occurs when radiation given at ultra-high dose rates spares healthy tissue while achieving isoeffective tumor control relative to conventional (CONV) dose rate irradiation. Limited data has implicated oxygen in the FLASH effect. This study investigated the effect of tissue oxygen tension (pO₂) on gastrointestinal (GI) FLASH sparing in mice.

Methods

pO₂ was quantified in vivo by electron paramagnetic resonance imaging (EPRI)- noninvasive oximetry through spin probe injection and magnetic resonance co-registration- and a phosphorescent quenching microsensor. B6(Cg)-Tyrc-2 J/J female mice were imaged while breathing 10%, 21%, and 95% oxygen. C57BL/6 mice of both sexes underwent microsensor probing and FLASH or CONV total abdominal

SUBMITTER: Waldrop T 

PROVIDER: S-EPMC12747515 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature