Morphogenesis and morphometry of brain folding patterns across species.

ABSTRACT: Evolutionary adaptations associated with the formation of a folded cortex in many mammalian brains are thought to be a critical specialization associated with higher cognitive function. The dramatic surface expansion and highly convoluted folding of the cortex during early development is a theme with variations that suggest the need for a comparative study of cortical gyrification. Here, we use a combination of physical experiments using gels, computational morphogenesis, and geometric morphometrics to study the folding of brains across different species. Starting with magnetic resonance images of brains of a newborn ferret, a fetal macaque, and a fetal human, we construct two-layer physical gel brain models that swell superficially in a solvent, leading to folding patterns similar to thos

SUBMITTER: Yin S 

PROVIDER: S-EPMC12747518 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature