Metabolomic Signatures of Prediabetes in Mexican Americans: The Role of Genetics and Macronutrients.

ABSTRACT: Prediabetes is one of the main health concerns in public health, and various etiological factors contribute to its onset. This study aimed to evaluate genetic associations and gene-macronutrient interaction with prediabetes-related metabolites to understand how genetic variation and dietary intake contribute to dysglycemia. We analyzed a total of 482 self-identified Mexican American participants recruited from Starr County, Texas in 2018-2019. Untargeted metabolomic profiling was performed using LC-MS. Nutrient densities of six macronutrients were derived from a 106-item food frequency questionnaire. Genetic associations for each metabolite were tested using Generalized linear Mixed Model Association Tests (GMMAT). Gene-macronutrient interactions on prediabetes-associated metabolites were

SUBMITTER: Chung S 

PROVIDER: S-EPMC12747543 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature