Astrocyte Interactions With Ti₃C₂T _<i>x</i> MXene Flakes: Insights Into Viability, Morphology, and Functionality.

ABSTRACT: Astrocytes, the most abundant cell type in the brain, are increasingly recognized as active regulators of neuronal function and potential therapeutic targets. Two-dimensional MXenes, such as titanium carbide (Ti₃C₂T_x), hold promise for neural interfaces and bioelectronic applications owing to their favorable electrochemical properties, but their compatibility with glial cells has yet to be investigated. Here, the first systematic evaluation of astrocyte-MXene interactions is reported by exposing cortical rat astrocytes to varying concentrations of Ti₃C₂T_x in aqueous dispersions. Phase contrast and scanning electron microscopy showed individual flakes and larger aggregates on astrocyte membranes with no detectable damage. Cyt

SUBMITTER: Boufidis D 

PROVIDER: S-EPMC12747572 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature