Radiofrequency thermocoagulation for the treatment of refractory focal status epilepticus.

ABSTRACT: This case study reports the first documented use of stereoelectroencephalography (SEEG)-guided radiofrequency thermocoagulation (RFTC) to treat refractory status epilepticus (RSE). A 33-year-old woman with drug-resistant epilepsy and recurrent RSE underwent SEEG to define her epileptogenic zone. A new RSE started shortly before and continued during the SEEG exploration, being unresponsive to multiple antiseizure medications, vagal nerve stimulation, and corticosteroid therapy. SEEG-signal quantification based on ictal biomarkers, that is, epileptogenicity index and connectivity epileptogenicity index, identified the epileptogenic zone network (EZN) within the mesial prefrontal, premotor, and parietal cortex, with major implication of the anterior-middle and posterior cingulate cortex. RFTC

SUBMITTER: Feys O 

PROVIDER: S-EPMC12747700 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature