Treatment Strategy and Residual Disease as Determinants of Survival in Stage IVB High-Grade Serous Ovarian Cancer: A Retrospective Cohort Study.

ABSTRACT:

Background and objective

Stage IVB high-grade serous ovarian cancer (HGSOC) carries a poor prognosis. We aimed to: (1) describe the characteristics and survival of patients treated with primary cytoreductive surgery (PCS), interval cytoreductive surgery (ICS) or chemotherapy alone, (2) investigate the correlation between disease distribution and treatment type, and (3) evaluate the impact of cytoreductive surgery (CS) "aggressiveness" and outcome on survival.

Methods

A single-center retrospective cohort study of Stage IVB HGSOC patients. Demographics, tumor characteristics, treatment including "aggressive" CS (upper abdominal and extraperitoneal procedures), and outcomes were analyzed using descriptive statistics and survival analysis, with nonparametric tests and Cox-propor

SUBMITTER: Benseler A 

PROVIDER: S-EPMC12747705 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature