Development and external validation of a prognostic nomogram for event-free survival in resectable non-small cell lung cancer after neoadjuvant chemoimmunotherapy.

ABSTRACT:

Background

Combining multiple prognostic factors can enhance risk assessment for resected non-small cell lung cancer (NSCLC). Our aim was to evaluate the prognostic significance of ypT staging, ypN staging, major pathologic response (MPR) and pathology response in lymph node, and to develop a combined prognostic model to predicting event-free survival in resectable NSCLC patients after neoadjuvant chemoimmunotherapy (NCI).

Methods and results

Two independent cohorts (derivation, n=208; external validation, n=91) were utilized. Pathologic assessment and ypTNM staging followed recommendations from the International Association for the Study of Lung Cancer (IASLC) and the 8th edition AJCC TNM classification. The evaluation of lymph node is documented according to IASLC recommen

SUBMITTER: Qu L 

PROVIDER: S-EPMC12747836 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature