Frailty index changes before and after incident cardiovascular disease.

ABSTRACT:

Background

Cardiovascular disease (CVD) and frailty are interrelated conditions prevalent in aging populations, yet their dynamic temporal relationship remains underexplored. This study investigates longitudinal changes in frailty trajectories before and after incident CVD across diverse cohorts.

Methods

Utilizing data from four longitudinal, multinational cohorts (ELSA, HRS, CHARLS, SHARE; n = 66,537), we constructed the frailty index (FI) based on age-related health deficits, using 40, 40, 42, and 44 items from ELSA, HRS, CHARLS and SHARE, respectively. Linear mixed models assessed FI changes pre- and post-CVD, adjusting for demographics, lifestyle, and baseline FI. Sensitivity analyses excluded hypertension, diabetes, and arthritis to mitigate confounding.

Resul

SUBMITTER: Qian XY 

PROVIDER: S-EPMC12747851 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature