Unmasking frailty in coronary artery disease: impact on outcomes after lower limb amputation.

ABSTRACT:

Background

Frailty is a major determinant of outcomes in patients with coronary artery disease (CAD) undergoing lower limb amputation. This study evaluates the impact of frailty on in-hospital outcomes in these patients.

Methods

We performed a retrospective analysis of the National Inpatient Sample (2016-2021) to identify adult patients with CAD who underwent lower limb amputation. Frailty was defined using the Johns Hopkins Adjusted Clinical Groups (ACG) frailty indicator. Multivariable logistic regression was used to assess the independent association of frailty with in-hospital outcomes, and propensity score matching (PSM) was performed to further account for confounding factors.

Results

After PSM, 9,990 patients were included in each cohort. Frail patients experie

SUBMITTER: Bahar AR 

PROVIDER: S-EPMC12747853 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature