Genetic polymorphisms in cGAS-STING-mediated type I interferon innate immune signaling pathway are associated with DLBCL.

ABSTRACT:

Background

Diffuse large B cell lymphoma (DLBCL) is a highly heterogeneous lymphoid neoplasm characterized by diverse gene expression profiles and genetic alterations, resulting in substantial variations in clinical features and response to therapy. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway plays a central role in innate immune response and affects the development of DLBCL. However, the relationship between genetic polymorphisms in genes involved in the cGAS-STING-mediated signaling pathway and their role in DLBCL remains underexplored.

Methods

A total of 147 patients with DLBCL and 247 healthy controls were recruited. Single nucleotide polymorphism (SNP) genotyping was conducted using the MassARRAY platform. We evaluated the associati

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC12747902 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature