High-altitude immune remodeling in children with <i>Mycoplasma pneumoniae</i> pneumonia: a multi-center transcriptome study.

ABSTRACT:

Introduction

A global outbreak of Mycoplasma pneumoniae pneumonia (MPP) emerged following the Corona Virus Disease 2019 (COVID-19) pandemic. Different altitudes significantly impact community-acquired pneumonia (CAP). Whether there are differences in the immune responses of children with MPP at different altitudes is unknown.

Methods

This study collected bronchoalveolar lavage fluid (BALF) from children with MPP in Nanjing (altitude, 20 m) or Qinghai (altitude, 4,058.40 m) for transcriptome sequencing analysis to investigate pulmonary immune responses in children with MPP at different altitudes.

Results

Children with refractory Mycoplasma pneumoniae pneumonia (RMPP) in the plateau group showed milder clinical manifestations, with shorter duration of feve

SUBMITTER: Luo Y 

PROVIDER: S-EPMC12747907 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature