Single-cell analysis reveals shared adaptive responses across different types of podocyte injury.

ABSTRACT:

Introduction

Podocytes are essential for maintaining the structural and functional integrity of the glomerular filtration barrier. Their damage constitutes a common pathological basis for proteinuria and renal function deterioration in kidney diseases. Podocyte injury exhibits marked heterogeneity in etiology, pathogenic mechanisms, and phenotypic manifestations across distinct kidney diseases, leading to different renal outcomes. However, the molecular underpinnings remain limited. Consequently, single-cell RNA sequencing (scRNA-seq) enables deconstruction of renal cell states with unprecedented resolution.

Methods

Here, we integrated 16 scRNA-seq samples of human kidney tissues, totaling 73,684 cells from healthy controls and patients with IgA nephropathy (IgAN), idiopathi

SUBMITTER: Yang L 

PROVIDER: S-EPMC12747916 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature