Metabolomic analysis of synovial fluid from healthy and pathological equine joints and tendon sheaths using high-resolution ¹H Nuclear Magnetic Resonance.

ABSTRACT:

Introduction

Joint and tendon sheath diseases are a major cause of lameness and reduced performance in horses. Synovial fluid composition changes in response to pathological processes and metabolomic profiling offers a promising approach to detect these alterations. While equine joint metabolomics has been explored, little is known about the metabolomic profile of tendon sheaths. This study aimed to characterize and compare the synovial fluid metabolomic profiles of healthy and pathological joints and tendon sheaths in horses using high-resolution ¹H Nuclear Magnetic Resonance spectroscopy, and to identify potential biomarkers associated with musculoskeletal pathology.

Methods

Synovial fluid samples were collected from healthy joints and tendon sheaths of routinel

SUBMITTER: Guadalupi M 

PROVIDER: S-EPMC12747927 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature