Case Report: Abscopal effect of radiotherapy in a patient with metastatic duodenal adenocarcinoma and resistance to chemoimmunotherapy.

ABSTRACT:

Background

Duodenal adenocarcinoma is a rare gastrointestinal malignancy, with limited clinical treatment data and a poor prognosis, especially when metastatic. Standard therapies such as chemotherapy and immunotherapy often exhibit limited efficacy, particularly in advanced stages of the disease. The abscopal effect, where local radiotherapy leads to regression of distant metastatic lesions, has been documented in various cancers but is not well explored in duodenal adenocarcinoma. This case report evaluates the potential for radiotherapy to induce an abscopal effect in a patient with metastatic duodenal adenocarcinoma resistant to chemotherapy and immunotherapy.

Objective

To explore the potential of radiotherapy to induce an abscopal effect and provide palliative benefits

SUBMITTER: Hao Y 

PROVIDER: S-EPMC12747931 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature