Resident CD24 ⁺LCN2 ⁺ LPCs aggravate fibrosis and inflammatory progression via the recruitment of TPPP3 ⁺COL10A1 ⁺ macrophages in NASH.

ABSTRACT: Resident CD24 ⁺LCN2 ⁺ liver progenitor cells (LPCs) reportedly contribute to the expanding ductular reaction and macrophage-mediated inflammation associated with chronic liver damage. Both ductular reactions and macrophage-driven inflammation are associated with liver fibrosis and injury in various mouse liver disorders. This study aims to investigate the molecular phenotypes of LPCs and their regulatory mechanisms in humans with non-alcoholic steatohepatitis (NASH). Single-cell RNA sequencing (scRNA-seq) datasets are used to characterize the status and molecular phenotypes of LPCs in clinical NASH samples. To elucidate the regulatory mechanisms of LPCs, CellChat and NicheNet are employed to assess cell-cell communication between LPCs and other cell types. The finding

SUBMITTER: Ding M 

PROVIDER: S-EPMC12747972 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature