A New Approach for Estimating Liver IVIM Fast Diffusion Coefficient in Two-Compartment Model and Fast Diffusion Fraction in Three-Compartment Model: Theory and In Vivo Validation of Two Centers' Data.

ABSTRACT: The intravoxel incoherent motion (IVIM) three-compartment model (3CM) potentially offers better classification for perfusion-rich pathologies. However, 3CM is often associated with less fitting stability than the two-compartment model (2CM). For liver intravoxel IVIM data, when the fit-starting b-value is adjusted from 2 s/mm² to b_i s/mm², PF_i, which indicates the perfusion fraction at b_i, gradually decreases as the initial fitting b-value b_i increases and eventually approaches zero. We define Y_i = ln [(1 - PF_i)/PF_i]. With a fitted line between Y_i and b_i, the intercept with the y-axis is the predicted value of Y₀ that follows the bi-exponential model. The PF

SUBMITTER: Ma FZ 

PROVIDER: S-EPMC12748020 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature