Prospective case-control cohort analysis of two-day/two-stage pelvic exenteration surgery: Safety, feasibility, acceptability and medium-term outcomes.

ABSTRACT:

Aim

Pelvic exenteration (PE) is the only curative option for extensive pelvic cancers. Advances have facilitated increasingly complex resectional and reconstructive components, including per-operative oncological adjuncts such as intraoperative radiotherapy. Cumulatively, these components increase operative duration beyond what is feasible within a single conventional operating day. Two-day/two-stage PE addresses this, but little is known about this approach. This study aims to evaluate the feasibility, safety and medium-term outcomes of a two-day/two-stage PE.

Method

Consecutive patients (2010-2025) from a prospectively maintained high-volume PE unit database (n = 373) undergoing two-day/two-stage PE were compared against a matched control cohort of single-day cases lasting

SUBMITTER: West CT 

PROVIDER: S-EPMC12748039 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature