Prevalence and Duration of Potential Drug-Drug Interactions Among US Nursing Home Residents, 2018-2020.

ABSTRACT:

Background

Nursing home (NH) residents are at increased risk of drug-drug interactions (DDIs) due to multimorbidity and polypharmacy. While prior research suggests that many DDIs lead to adverse drug events in older adults, the extent of exposure to potentially clinically relevant DDIs among United States (US) NH residents is largely unknown.

Methods

In this cohort study, we calculated the prevalence and duration of exposure to 98 potential DDIs among US NH residents from 2018 to 2020. DDIs were sourced from three expert consensus publications, some of which defined similar interactions and overlapping drug combinations, allowing comparisons within and across lists. Data were drawn from Medicare claims linked to Minimum Data Set 3.0 clinical assessments. Eligible residents i

SUBMITTER: Reich LA 

PROVIDER: S-EPMC12748051 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature