Circulating Proteomics Identifies a Dynamic Profile of Hepatic Steatosis During Metabolic Intervention.

ABSTRACT:

Background

Weight reduction through lifestyle, activity, and dietary interventions are the mainstay of initial therapy for metabolic dysfunction associated steatotic liver disease. Data on the relative effectiveness and metabolic pathways linking weight loss and decreased hepatic steatosis are lacking. We sought to identify coordinated changes between the circulating proteome and hepatic steatosis within a randomized clinical trial of alternate day fasting and exercise and prioritize proteins relevant to hepatic steatosis within a broader context using a community cohort.

Methods and results

We quantified a broad cardiometabolic proteome (>300 proteins) in 67 individuals randomized in a 2×2 factorial design to alternate day fasting and exercise before and after the 3-month i

SUBMITTER: El-Sabawi B 

PROVIDER: S-EPMC12748073 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature