Ring Finger Protein 2 Promotes Oxidative Stress and Mitochondrial Dysfunction in Doxorubicin-Induced Cardiotoxicity Via the Mercaptopyruvate Sulfurtransferase/Hydrogen Sulfide Pathway.

ABSTRACT:

Background

Doxorubicin, a broad-spectrum chemotherapy drug, is often associated with dosage-dependent cardiotoxicity, which results in its limited clinical application. A therapeutic dose of doxorubicin can activate cardiac ubiquitin-proteasome system, whereas the role and potential mechanisms of this process in doxorubicin-induced cardiomyopathy (DIC) remain unclear. Herein, we assessed the potential role and therapeutic value of RNF2 (ring finger protein 2) on doxorubicin-induced cardiac damage.

Methods

Cardiomyocyte-specific RNF2 knockout or overexpression mice received doxorubicin intraperitoneal injection to establish the DIC model. The effects of RNF2 and its downstream mediators were explored through RNA sequencing, immunoprecipitation mass spectrometry analysis, and

SUBMITTER: Zhong Y 

PROVIDER: S-EPMC12748078 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature