Paradigm shift in patients with multiple brain metastases from whole brain radiotherapy to high precision multimodality treatment including stereotactic radiotherapy.

ABSTRACT:

Background

Whole brain radiotherapy (WBRT) is increasingly being replaced by high precision multimodality treatment including stereotactic radiotherapy (SRT) in patients with ≥ 4 brain metastases (BMs). The implications of this trend on survival rates are uncertain. Our study examines the time trends for survival rates of patients treated with radiotherapy for brain metastases during this era of shifting treatment paradigms.

Methods

Patients with newly diagnosed BMs treated with SRT or WBRT between 2010 and 2023 were included, regardless of the number of brain metastases or the primary malignancy. Patients were excluded if they had previously undergone cranial radiotherapy. Differences in survival between treatment years were evaluated using Log-rank tests. A P value of ≤ 0.

SUBMITTER: Crouzen J 

PROVIDER: S-EPMC12748092 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature