Neuromodulation in Parkinson's disease with transcranial pulse stimulation: evidence of clinical efficacy and cortical oscillatory changes.

ABSTRACT:

Background

Parkinson's disease (PD) is a progressive neurodegenerative disorder for which current pharmacological treatments, while initially effective, often lead to long-term motor fluctuations and complications. Transcranial pulse stimulation (TPS) is a novel non-invasive neuromodulation technique that uses mechanical stimuli through shockwaves to induce neuroplasticity.

Methods

This open-label, single-arm pilot study enrolled 14 individuals with PD who received 12 TPS sessions over 4 weeks. Stimulation targeted motor and symptom-specific cortical regions. Outcomes were assessed across motor, non-motor domains, and EEG at baseline, after 3, 6, 9, and 12 sessions, and at 1-month follow-up.

Results

TPS produced significant and consistent improvements across different

SUBMITTER: Gianlorenco AC 

PROVIDER: S-EPMC12748141 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature