Different beta-blockers for preventing arrhythmic events in patients with long QT syndrome: a network meta-analysis.

ABSTRACT:

Objective

This study aims to compare the efficacy of different types of beta-blockers in preventing arrhythmias in patients with long QT syndrome (LQTS), and simultaneously analyze the relationship between dose and effect within each drug by incorporating dose as a continuous covariate.

Methods

A systematic search was conducted in the electronic database, with the cutoff date set at July 20, 2025. The search scope was limited to observational studies that compared at least two drug strategies. A Bayesian arm random-effects network meta-analysis (NMA) was performed, in which the daily equivalent dose (mg/day) was included as a continuous covariate to explore the dose-response relationship.

Results

This analysis included 5,692 patients with LQTS from 10 cohort studies.

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC12748156 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature