Pore morphology of bijel-templated materials promotes migration and downregulates αSMA expression in human fibroblasts.

ABSTRACT: The efficacy of an implanted biomaterial is dependent on its ability to mitigate the foreign body response (FBR). Consequently, advancements in biomaterials design often focus on their immunomodulatory capability. Porous scaffolds have proven especially useful due to their capacity for cell infiltration and biomimicry of native tissues. Specifically, substrates with distinct microstructures have been shown to reduce fibrotic production and increase vascularization in vivo. Investigation of the direct relationship between FBR-implicated cell behavior and these materials, known as bicontinuous interfacially jammed emulsion gels (bijel)-templated materials (BTMs), has not yet been performed experimentally. In this study, we examine the influence of BTMs on the characteristics of human

SUBMITTER: Gonthier AR 

PROVIDER: S-EPMC12748194 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature