Activation of nuclear receptors correlates with tuberculosis severity and is a target for host-directed therapy.

ABSTRACT:

Introduction

The immune response to Mycobacterium tuberculosis is accompanied by metabolic adaptations that fuel host immunity, but that are exploited by the pathogen to ensure persistence and growth. Activation of nuclear receptors, such as liver-X-receptors (LXR), orchestrate macrophage immunometabolic adaptations to infection and globally associate with tuberculosis (TB) protection.

Methods

We interrogated available transcriptomic datasets of whole blood from TB patients or M. tuberculosis aerosol-infected mice to assess the expression of the signal by nuclear receptors (SNR) and LXR pathways and its correlation with disease severity. In vitro (macrophages) and in vivo (mouse model) M. tuberculosis infections were used for functional validation of the

SUBMITTER: Maceiras AR 

PROVIDER: S-EPMC12748203 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature