The impact of red blood cell storage duration on clinical outcomes in pediatric cardiac surgery: a systematic review and meta-analysis.

ABSTRACT:

Background

The impact of red blood cell (RBC) storage duration during cardiopulmonary bypass (CPB) priming in pediatric cardiac surgery remains unclear.

Objective

To evaluate whether RBC storage time affects perioperative outcomes in children undergoing cardiac surgery.

Methods

We performed a systematic review and meta-analysis of studies comparing fresh vs. longer-stored RBCs for CPB priming in pediatric patients. Databases searched included PubMed, EMBASE, Cochrane Library, and Web of Science (through May 2025). Primary outcomes were mortality, infection/sepsis, respiratory complications, and multiple organ dysfunction syndrome (MODS); secondary outcomes included mechanical ventilation duration, ICU stay, and intraoperative lactate levels.

Results

Ten studies

SUBMITTER: Jin X 

PROVIDER: S-EPMC12748228 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature