Temporal modulation of gene expression in a controlled <i>Schistosoma mansoni</i> human infection model.

ABSTRACT:

Background

Schistosomiasis is caused by parasitic blood flukes of the genus Schistosoma. Despite ongoing mass drug administration efforts, the disease remains a major public health burden in endemic regions. A better understanding of early host responses to schistosomiasis is critical for developing effective vaccines and therapeutics.

Methods

We conducted a longitudinal transcriptomic study of peripheral blood samples from 30 Schistosoma-naïve volunteers participating in two controlled human infection trials with male- or female-only S. mansoni cercariae. Blood was collected at six time points over 20 weeks post-infection. Whole-transcriptome RNA sequencing and integrative analyses, including differential gene expression, gene set enrichment, protein in

SUBMITTER: Li D 

PROVIDER: S-EPMC12748245 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature