Efficacy of Submucosal Polydeoxyribonucleotide Injection after Impacted Mandibular Third Molar Extraction: A Randomized Controlled Trial.

ABSTRACT:

Purpose

This study aimed to evaluate the efficacy of polydeoxyribonucleotide (PDRN) injection after impacted mandibular third molar (IMTM) extraction. The primary outcome was postoperative pain, while secondary outcomes included postoperative swelling, periodontal pocket depth, and patient-reported outcome.

Materials and methods

Thirty medically uncompromised patients who underwent bilateral extraction of IMTMs were enrolled in the clinical study. PDRN was randomly injected on the experimental side, while normal saline was injected on the control side. Postoperative pain was assessed using a visual analog scale. Postoperative swelling was evaluated via linear measurements based on the Laskin method. Furthermore, three-dimensional volumetric analysis was conducted by superimp

SUBMITTER: Kim HJ 

PROVIDER: S-EPMC12748270 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature