Chewable Tablets for Precise Unit Dosing of Animals.

ABSTRACT:

Introduction

Peroral administration of preclinical drugs is commonly achieved through oral gavage or food formulations. However, oral gavage induces distress and is unsuitable for behavior studies, whereas food mixing and delivery are less precise. Therefore, we manufactured and tested tablets with the appropriate physical properties for precise unit dosing of laboratory mice.

Methods

Various tablet compositions were evaluated for compactability and compressibility and tested for voluntary consumption by CD-1 mice. The most bitter compound known, denatonium benzoate, was added to tablets at escalating doses, and daily consumption by male and female CD-1 mice was measured across four weeks.

Results

Tablet consumption increased with the number of exposures in 5 of 6 mic

SUBMITTER: Landes RE 

PROVIDER: S-EPMC12748284 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature