Sex hormone receptor signaling networks drive pancreatic solid-pseudopapillary neoplasm pathogenesis and therapy.

ABSTRACT: Solid-pseudopapillary neoplasm of the pancreas (SPN) represents a rare pancreatic tumor with a low malignant potential, predominantly affecting young women. This suggests a potential involvement of sex hormones in the development of the tumor. Research has demonstrated the expression of progesterone receptor (PR), estrogen receptor β (ERβ), and androgen receptor (AR) in certain SPN tumor cells, with the activation of these receptors potentially contributing to tumor growth and proliferation. Sex hormones and their receptors modulate these multiple signaling pathways, influencing the progression of SPN at various levels. Notably, the CTNNB1 mutation serves as a pivotal driver of SPN, leading to the inhibition of β-catenin degradation and its nuclear translocation, as well as the abnormal ac

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12748345 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature