A pan-cancer analysis of CTSC as a candidate prognostic and immune-related biomarker.

ABSTRACT:

Background

Cathepsin C (CTSC) is a lysosomal protease involved in immune regulation and inflammatory responses, with emerging roles in tumor progression and microenvironment remodeling. Although CTSC dysregulation has been observed in several cancers, its pan-cancer significance, immune-related functions, and clinical relevance remain poorly characterized.

Methods

We conducted an integrated multi-omics analysis using data from TCGA, GTEx, CPTAC, cBioPortal, HPA, and other public databases. We evaluated CTSC expression patterns, prognostic value, immune infiltration, epigenetic regulation, mutation profiles, and drug sensitivity across diverse cancer types. Analytical methods included survival analysis, functional enrichment, immune correlation assays, and single-cell sequenc

SUBMITTER: Zheng L 

PROVIDER: S-EPMC12748366 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature