The role of genes related to excitotoxicity in glioma prognosis.

ABSTRACT:

Background

Gliomas pose a significant challenge in the realm of neuro-oncology, marked by high rates of morbidity and mortality, as well as substantial healthcare costs. Current treatment strategies include surgical procedures, radiation therapy, and chemotherapy. However, these approaches often face obstacles due to tumor heterogeneity and the high risk of recurrence. Unraveling the molecular pathways that drive glioma progression is crucial for developing improved therapeutic options. This study investigates the prognostic relevance of excitotoxicity-related genes (ERGs) in the context of glioma.

Method

A comprehensive bioinformatic analysis was performed using publicly available glioma datasets. We developed and validated a prognostic risk model based on five ERGs, and co

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC12748369 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature