Insights into cannabinoid receptor 2 (CB2) anterograde trafficking and pharmacological chaperoning.

ABSTRACT: Cannabinoid Receptor 2 (CB₂) is a promising therapeutic target for modulating inflammation. Canonical signalling responses to receptor ligands are critically dependent on cell surface receptor expression. However, it is also now appreciated that intracellular G protein-coupled receptors can contribute to signalling responses and influence functional outcomes. Therefore, understanding how the subcellular distribution of receptors is controlled is also highly pertinent. CB₂ is observed to be expressed at the cell surface as well as having a considerable proportion expressed intracellularly. Despite this distribution being well established, little is known about the regulation of CB₂ anterograde trafficking and subcellular distribution. We report that sustaine

SUBMITTER: Oyagawa CRM 

PROVIDER: S-EPMC12748375 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature