Lactylation-related lncRNAs can forecast prognosis and immune response of lung adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) represents a significant proportion of lung cancer cases, with immunotherapy serving as a cornerstone of treatment. Although immunotherapy has advanced significantly, the prognosis for patients in advanced stages remains suboptimal. Lactylation, a newly discovered metabolic pathway, has been recognized as a critical mechanism driving the initiation and development of many cancers, including LUAD. Using machine learning, this research aims to pinpoint lactylation-related lncRNAs (LRLs) that could serve as prognostic markers in LUAD, shedding light on tumor development and novel therapeutic avenues.

Results

Four LRLs (AC090115.1, AC092718.4, AC092718.6, and AL451064.1) were incorporated into a prognostic model. This model successfully cate

SUBMITTER: Zhou L 

PROVIDER: S-EPMC12748385 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature