Metastatic patterns and survival outcomes across molecular subtypes in a large cohort of breast cancer patients from the Shiraz breast cancer registry.

ABSTRACT:

Purpose

Breast cancer molecular subtypes significantly influence metastatic behavior and survival outcomes. However, data on subtype-specific patterns of distant metastasis and prognosis in Middle Eastern populations remain scarce. This study addresses this gap by analyzing a large cohort from southern Iran to better characterize these differences and aid personalized treatment.

Methods

In this study, 8,491 women with breast cancer from the Shiraz Breast Cancer Registry were analyzed. Patients had known molecular subtypes based on estrogen receptor, progesterone receptor, and HER2 status, and no distant metastases at diagnosis. Patients were followed up until December 30, 2024. Kaplan-Meier, restricted mean survival time and Cox proportional hazards models assessed overall s

SUBMITTER: Akrami M 

PROVIDER: S-EPMC12748407 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature