Cellular senescence related gene signature predicts prognosis and immune features in skin cutaneous melanoma.

ABSTRACT:

Background

Skin cutaneous melanoma (SKCM) is the deadliest skin cancer, with rising global incidence. Cellular senescence plays an essential role in tumorigenesis, progression, and immune modulation in cancer, however, its role in SKCM prognosis and immunotherapy response remains unclear.

Methods

We analyzed 279 senescence-related genes (SRGs) in 469 patients with SKCM from The Cancer Genome Atlas. A cellular senescence-related signature (CSRS) was constructed using univariate and LASSO Cox regression analyses. Kaplan-Meier survival curves and receiver operating characteristic (ROC) analyses were used to evaluate its predictive performance. Consensus clustering based on SRG expression stratified patients into distinct subgroups. External validation was performed using the GS

SUBMITTER: Li M 

PROVIDER: S-EPMC12748409 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature