Predictive molecular alterations of prostate cancer brain metastases based on a companion diagnostic assay.

ABSTRACT: The current first-line treatment standard for patients with metastatic prostate cancer (mPCa), is a combination of androgen deprivation therapy (ADT) and androgen receptor pathway inhibitors (ARPI), plus the addition of docetaxel for fit patients with high-volume or high-risk disease. This upfront treatment is highly effective, however, the emergence of acquired resistance is nearly universal, upon which, molecular predictive biomarkers are needed for further targeted therapies. Genomic studies have identified a population of 20-30% prostate cancer (PCa) patients harboring tumor DNA damage repair (DDR) alterations. Recent clinical trials have shown that treatment with PARP inhibitors (PARPi) achieve high response rates in tumors with BRCA1- and BRCA2-pathogenic alterations. Patients with m

SUBMITTER: Rodriguez-Calero A 

PROVIDER: S-EPMC12748413 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature