Insulin edema in slowly progressive type 1 diabetes: improvement following adjustment of insulin therapy.

ABSTRACT: Insulin edema is an uncommon complication that typically arises soon after initiating insulin therapy, most often in individuals with newly diagnosed diabetes or poorly controlled hyperglycemia. An old report from a single hospital in Africa showed an incidence of 3.5% among 491 insulin-treated individuals. Although the precise pathophysiology remains uncertain, proposed mechanisms include insulin-induced sodium retention, increased vascular permeability, and dysregulation of the renin-angiotensin-aldosterone system. Insulin edema has been described in both type 1 and type 2 diabetes; however, occurrence in slowly progressive type 1 diabetes mellitus (SPIDDM) is exceptionally rare. We report a woman with SPIDDM who developed bilateral lower-leg edema shortly after starting basal-bolus insu

SUBMITTER: Okamura E 

PROVIDER: S-EPMC12748414 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature