Cuproptosis-related gene DLD expression correlates with the prognosis and tumor immune microenvironment in clear cell renal cell carcinoma.

ABSTRACT:

Background

Cuproptosis, or copper-induced programmed cell death, shows promise in cancer therapy. However, the role of the copper-related gene dihydrofatty acyl dehydrogenase (DLD) in the prognosis of renal clear cell carcinoma (KIRC) remains unclear.

Methods

Raw data from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were analyzed using R. DLD expression in cancer was evaluated through these databases, and its correlation with tumor immunological features was assessed using the TIMER and TISIDB databases.

Result

The results demonstrated that DLD is downregulated in KIRC, providing diagnostic and prognostic value. Cox regression identified DLD expression as a protective factor. GO and KEGG analyses revealed DLD-associated gene pathways, while its ex

SUBMITTER: Qian C 

PROVIDER: S-EPMC12748422 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature