Tailored radiotherapy for brain metastases improves precision and outcomes.

ABSTRACT: Brain metastases represent a significant clinical challenge in oncology, affecting a considerable proportion of cancer patients and traditionally linked to a poor prognosis. This review explores the evolving role of radiotherapy, emphasizing the shift from whole-brain radiation therapy (WBRT) to precise modalities like stereotactic radiosurgery (SRS) and surgical resection. Recent progress in systemic therapies, such as targeted therapies and immunotherapies, has transformed treatment strategies, particularly for melanoma and specific non-small cell lung cancer (NSCLC) genotypes. These advancements are supported by prognostic tools like the Graded Prognostic Assessment (GPA), which combines clinical and molecular data to refine outcome predictions and guide therapy. For patients with favor

SUBMITTER: Bao J 

PROVIDER: S-EPMC12748433 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature