Akkermansia muciniphila alleviates metabolic disorders through gut microbiota-mediated tryptophan regulation.

ABSTRACT: High-fat diet (HFD) consumption poses a significant public health threat due to its strong association with obesity, hyperlipidemia, cardiovascular diseases, and metabolic syndrome. While Akkermansia muciniphila has emerged as a promising probiotic for ameliorating metabolic disorders, the underlying mechanisms-specifically its interplay with intestinal tryptophan metabolism-remain poorly understood. Here, we demonstrate that A. muciniphila supplementation mitigates HFD-induced metabolic dysfunction in zebrafish by orchestrating a gut microbiota-tryptophan metabolite-AhR signaling axis. Firstly, A. muciniphila treatment effectively reduced the final weight of zebrafish, partially mitigated weight gain caused by HFD, and improved survival rate. In addition, A. muciniphila treatment reduced

SUBMITTER: Zhang F 

PROVIDER: S-EPMC12748435 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature