Hsa_circ_0062522 affects the progression and tamoxifen resistance of estrogen receptor-positive breast cancer by targeting miR-3163.

ABSTRACT:

Background

Multiple circRNAs are abnormally expressed in breast cancer (BC), which may be involved in tumor progression and promote anti-tumor drug resistance.

Aim

To explore the effect of hsa_circ_0062522 on the development of estrogen receptor-positive (ER+) breast cancer and tamoxifen (TAM) resistance.

Materials and methods

This study collected a total of 112 paired ER + breast cancer tumour tissues and adjacent tissues. The expression of hsa_circ_0062522 and miR-3163 in ER + breast cancer tissues and cells were determined by RT-qPCR. The cell viability, migration and apoptosis of MCF-7 and T-47D were determined by CCK-8, transwell and flow cytometry assays. Spearman correlation analysis and dual luciferase assay were perfprmed to verify the interaction between hsa

SUBMITTER: Bian Y 

PROVIDER: S-EPMC12748444 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature