Prognostic significance of circulating tumor DNA in non-metastatic colorectal cancer.

ABSTRACT:

Purpose

Circulating tumor DNA (ctDNA) is the small fragments of DNA released by tumor cells into the blood. By detecting the abnormal changes in ctDNA in the blood, it can assist in the early screening of cancer, monitoring of treatment efficacy, early warning of recurrence, and guidance for individualized treatment. Using a systematic review and meta-analysis approach, in this study, we assessed the significant prognostic value of ctDNA in non-metastatic colorectal cancer (CRC) patients.

Methods

Studies on the predictive value of ctDNA in CRC were considered. RevMan 5.3 was used to conduct meta-analyses and subgroup investigations classified by tumor population, two-year or three-year DFS, and tumor location. The analysis included 11 trials conducted with 605 individuals. D

SUBMITTER: Li R 

PROVIDER: S-EPMC12748447 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature