Identification of FGF14-AS2/MPP2 axis as prognostic biomarkers in colorectal cancer based on CeRNA network.

ABSTRACT:

Background

Colorectal cancer (CRC) remains a major global health challenge due to its high morbidity and mortality, even with recent advancements in diagnosis and treatment. Increasing evidence suggests that competitive endogenous RNA (ceRNA) regulatory networks play pivotal roles in the pathogenesis of various cancers, including CRC. However, the potential application of ceRNA networks in CRC diagnosis and their underlying mechanisms remain insufficiently explored.

Methods

The gene expression profiles and clinical information of CRC were extracted from TCGA database and GEO databases. Differential expression genes (DEGs) were identified using bioinformatics analyses, a ceRNA network was constructed via Cytoscape. Functional enrichment was assessed through GO and KEGG analys

SUBMITTER: Zhou R 

PROVIDER: S-EPMC12748477 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature