Higher cerebellum florbetapir uptake in cerebral amyloid angiopathy compared to Alzheimer's disease: A dual florbetapir and FDG PET study.

ABSTRACT:

Background

Amyloid-β (Aβ) is the primary amyloidogenic protein involved in various diseases associated with cognitive dysfunction, including Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA).

Objective

This cross-sectional study aimed to investigate the characteristics of ¹⁸F-florbetapir PET, which detects Aβ deposition, and ¹⁸F-FDG PET, which measures glucose metabolism in patients with CAA and AD.

Methods

30 patients with AD, 37 with probable CAA, and 14 control subjects (CSs) underwent ¹⁸F-florbetapir and ¹⁸F-FDG PET imaging within a one-month period. Region of interest and voxel-wise analyses were performed to compare Aβ deposition and glucose metabolism patterns among the three study groups. Standardized up

SUBMITTER: Sha Y 

PROVIDER: S-EPMC12748501 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature